Buprenorphine (BUP) Drug Test
Buprenorphine is a synthetic thebaine derivative that has both analgesic and opioid antagonist properties. As an analgesic, it is about 25 to 40 times more potent than morphine. Symptoms of overdosage include confusion, dizziness, pinpoint pupils, hallucinations, hypotension, respiratory difficulty, seizures, and coma. Buprenorphine is metabolized in man primarily by N-dealkylation and conjugation to form norbuprenorphine, which is pharmacologically active, and conjugates of buprenorphine and norbuprenorphine. Within 144 hours of a single intramuscular dose of the drug, 95% is eliminated, with 68% in the feces and 27% in the urine. Buprenorphine and its metabolites that are detected in urine are buprenorphine, norbuprenorphine, Buprenorphine-3-beta-D-glucuronide, and Norbuprenorphine-3-beta-D-glucuronide.